R William Caldwell Selected Research

Intraperitoneal Injections

1/2022

Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury.

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R William Caldwell Research Topics

Disease

9	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 11/2003
7	Hyperglycemia 01/2023 - 11/2005
7	Inflammation (Inflammations) 01/2022 - 02/2010
6	Reperfusion Injury 01/2022 - 09/2006
5	Ischemia 01/2022 - 11/2016
5	Cardiovascular Diseases (Cardiovascular Disease) 02/2020 - 11/2006
4	Retinopathy of Prematurity (Retrolental Fibroplasia) 01/2022 - 01/2014
4	Fibrosis (Cirrhosis) 01/2015 - 02/2010
3	Hypoxia (Hypoxemia) 01/2022 - 11/2011
3	Pathologic Neovascularization 11/2014 - 06/2005
3	Erectile Dysfunction 06/2013 - 03/2011
3	Hypertension (High Blood Pressure) 01/2013 - 11/2006
2	Brain Injuries (Brain Injury) 01/2022 - 01/2020
2	Retinal Neovascularization 01/2022 - 01/2014
2	Optic Nerve Injuries 01/2022 - 01/2018
2	Obesity 01/2020 - 11/2017
2	Neoplasms (Cancer) 01/2018 - 04/2012
2	Ganglion Cysts (Ganglion) 11/2016 - 07/2011
2	Glaucoma 11/2016 - 07/2011
2	Vision Disorders (Hemeralopia) 11/2016 - 07/2011
2	Diabetes Complications 02/2016 - 04/2005
2	Hyperoxia 01/2014 - 09/2013
1	Disease Progression 01/2022
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2022
1	Brain Infarction 01/2022
1	Hyperlipidemias (Hyperlipidemia) 01/2022
1	Brain Ischemia (Cerebral Ischemia) 01/2022
1	Macular Edema 01/2022
1	Ischemic Stroke 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 11/2021
1	Cardiomegaly (Heart Hypertrophy) 01/2021
1	Cardiotoxicity 01/2021
1	Central Nervous System Diseases (CNS Diseases) 02/2020
1	Stroke (Strokes) 02/2020
1	Multiple Sclerosis 01/2020
1	Brain Diseases (Brain Disorder) 01/2020
1	Body Weight (Weight, Body) 11/2017
1	Weight Gain 11/2017
1	Hemorrhagic Shock 01/2017
1	Optic Nerve Diseases (Optic Neuropathy) 11/2016
1	Blindness (Hysterical Blindness) 11/2016
1	Osteoporosis 02/2016
1	Vascular Diseases (Vascular Disease) 03/2015
1	Vascular System Injuries 01/2014
1	Papilledema 09/2013
1	Infections 09/2013
1	Edema (Dropsy) 09/2013
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2013
1	Leukostasis 01/2013

Drug/Important Bio-Agent (IBA)

29	ArginaseIBA 01/2023 - 02/2010
11	Retinaldehyde (Retinal)IBA 01/2022 - 01/2014
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2015 - 11/2003
5	Arginine (L-Arginine)FDA Link 01/2022 - 11/2006
5	Protein Isoforms (Isoforms)IBA 01/2020 - 01/2013
4	Oxygen (Dioxygen)IBA 01/2022 - 01/2014
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 11/2005
4	EnzymesIBA 01/2022 - 01/2015
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2006
4	Angiotensin IIIBA 01/2015 - 05/2011
3	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2019 - 09/2006
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2015 - 12/2011
2	UreohydrolasesIBA 01/2022 - 01/2018
2	Phosphotransferases (Kinase)IBA 02/2019 - 01/2019
2	AcidsIBA 11/2017 - 01/2014
2	CollagenIBA 01/2015 - 11/2011
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2015 - 11/2006
2	Simvastatin (Zocor)FDA LinkGeneric 07/2008 - 07/2006
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2022
1	CytokinesIBA 01/2022
1	ChloridesIBA 01/2022
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 11/2021
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021
1	PC6 extract (PC6)IBA 01/2021
1	InflammasomesIBA 01/2020
1	p38 Mitogen-Activated Protein KinasesIBA 01/2019
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2018
1	OrnithineIBA 01/2018
1	Blood Glucose (Blood Sugar)IBA 11/2017
1	DCC ReceptorIBA 01/2017
1	Netrin-1IBA 01/2017
1	Hydroxyproline (4 Hydroxyproline)IBA 01/2015
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2015
1	Endothelins (Endothelin)IBA 11/2014
1	Peroxynitrous Acid (Peroxynitrite)IBA 01/2014
1	rho-Associated KinasesIBA 06/2013
1	Desoxycorticosterone (Deoxycorticosterone)IBA 01/2013
1	SaltsIBA 01/2013
1	Desoxycorticosterone Acetate (DOCA)FDA Link 01/2013
1	MineralocorticoidsIBA 01/2013
1	Acetates (Acetic Acid Esters)FDA Link 01/2013
1	Antihypertensive Agents (Antihypertensives)IBA 01/2013

Therapy/Procedure

6	Therapeutics 01/2022 - 11/2006
2	Lasers (Laser) 09/2013 - 06/2005
2	Light Coagulation 09/2013 - 06/2005
1	Intraperitoneal Injections 01/2022
1	Electroacupuncture 01/2021
1	Resuscitation 01/2017
1	Injections 09/2013
1	Intraocular Injections 09/2013